Toward Identifying Immune Dysfunction Signatures in Myelodysplastic Neoplasms

28 March 2023

Speakers:
Susann Winter, University Hospital Carl Gustav Carus
Shahram Kordasti, King's College London

Myelodysplastic neoplasms (MDS) are acquired clonal hematologic disorders that manifest themselves through ineffective hematopoiesis, concomitant peripheral cytopenias, genetic instability and immune dysfunction. MDS patients may have clinical features ranging from autoinflammatory to autoimmune disease states. Therefore, an important goal of immune profiling in MDS is to identify patient subgroups that would benefit from treatment with a particular immunotherapy due to an underlying disease-related immune signature.

Watch this webinar to learn how a combination of a ready-to-use high-dimensional flow cytometry assay and other techniques allowed us to focus on a common subgroup of patients harboring somatic mutations in a crucial splicing factor and discuss potential genotype-immunophenotype correlations that may affect the immune response, disease course, and clinical outcomes.